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KMID : 0616120120430040291
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 4 p.291 ~ p.296
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Study on the Essential Oils from the Roots of Angelica decursiva and Peucedanum praeruptorum
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Lim Hye-Rim
Shin Seung-Won
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Abstract
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The dried roots of Angelica decursiva and Peucedanum praeruptorum are registered as the official sources for the drug ’Junho’ in Korean Herbal Pharmacopoeia. In this study the essential oils were extracted from the roots of the two plants by steam distillation. Their compositions and the biological activities were compared. As the results of GC and GC-MS analysis, forty one and thirty five compounds were identified in the essential oils of Angelica decursiva and Peucedanum praeruptorum, respectively. Both of the two essential oils contained α-pinene as the most abundant component. They showed similar significant antioxidant activities in DPPH scavenging assay, and reducing power test. Their dose dependent inhibitions of the nitrosamine formation were identified in experiment using BHA as control. In MTT test of three cancer cell lines, HeLa, MCF-7 and SK-Hep-1, the essential oil from A. decursiva showed stronger activities than that of P. praeruptorum and their common main component, α-pinene.
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KEYWORD
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Angelica decursiva , Peucedanum praeruptorum , Essential oil , Antioxidant , DPPH , Reducing power , Nitrosamine , HeLa , MCF-7 , SK-Hep-1
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